Structure of PDB 3t5o Chain A Binding Site BS02

Receptor Information
>3t5o Chain A (length=871) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETR
ECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL
VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER
DCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV
KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHVPIFYSSK
RSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVF
LKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKN
SGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAE
KSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELA
PIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTE
CLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRE
CNNPAPQRGGKRCEGEKRQEEDCTPCINDDEEDSGCPQPVPPENGFIRNE
KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPV
VQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNS
LTCEKDTGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTS
PACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCG
YDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICE
VGTIRCANRKMEILHPGKCLA
Ligand information
Ligand IDFUL
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6-/m0/s1
InChIKeySHZGCJCMOBCMKK-KGJVWPDLSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@H](O1)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
CACTVS 3.341C[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namebeta-L-fucopyranose;
beta-L-fucose;
6-deoxy-beta-L-galactopyranose;
L-fucose;
fucose;
6-DEOXY-BETA-L-GALACTOSE
ChEMBLCHEMBL1230861
DrugBankDB03283
ZINCZINC000001532813
PDB chain3t5o Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3t5o Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
Resolution2.869 Å
Binding residue
(original residue number in PDB)		T371 E372
Binding residue
(residue number reindexed from 1)		T354 E355
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0045087 innate immune response
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3t5o, PDBe:3t5o, PDBj:3t5o
PDBsum3t5o
PubMed22267737
UniProtP13671|CO6_HUMAN Complement component C6 (Gene Name=C6)

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