Structure of PDB 3sz2 Chain A Binding Site BS02

Receptor Information
>3sz2 Chain A (length=530) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKAL
RDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVAR
RYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLA
HMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLER
VLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLK
STYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQ
RIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTET
ASDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPK
VRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMP
VQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARL
AKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3sz2 KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 T544 T569 A570 T571 S575 S576 S577 D578 N580 Y671 S674 R677 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N191 N193 S194 T252 T277 A278 T279 S283 S284 S285 D286 N288 Y369 S372 R375 R426 R444 M445 N448 Q452
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3sz2, PDBe:3sz2, PDBj:3sz2
PDBsum3sz2
PubMed22660438
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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