Structure of PDB 3syz Chain A Binding Site BS02

Receptor Information
>3syz Chain A (length=540) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKAL
RDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVAR
RYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLA
HMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLER
VLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLK
STYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQ
RIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTET
ASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAF
IERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVRE
AAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAP
KERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
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PDB3syz KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry.
Resolution1.952 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 A570 R573 S575 S576 S577 D578 N580 R587 E615 R660 K663 T664 F667 G668 Y671 M673 E681 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N191 N193 S194 S251 T252 T277 A278 R281 S283 S284 S285 D286 N288 R295 E323 R368 K371 T372 F375 G376 Y379 M381 E389 R436 R454 M455 N458 Q462
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3syz, PDBe:3syz, PDBj:3syz
PDBsum3syz
PubMed22660438
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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