Structure of PDB 3sv4 Chain A Binding Site BS02

Receptor Information
>3sv4 Chain A (length=533) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKAL
RDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVAR
RYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLA
HMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLER
VLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLK
STYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQ
RIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTET
ASWMVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQS
FPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAF
NMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAV
ARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
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PDB3sv4 KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		N485 S486 S543 T544 T569 A570 T571 R573 S575 S576 S577 D578 N580 E615 K663 T664 F667 G668 Y671 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N193 S194 S251 T252 T277 A278 T279 R281 S283 S284 S285 D286 N288 E323 K364 T365 F368 G369 Y372 R429 R447 M448 N451 Q455
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3sv4, PDBe:3sv4, PDBj:3sv4
PDBsum3sv4
PubMed22660438
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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