Structure of PDB 3s9c Chain A Binding Site BS02

Receptor Information
>3s9c Chain A (length=234) Species: 343250 (Daboia siamensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGDECNINEHPFLVALYTSASSTIHCAGALINREWVLTAAHCDRRNIR
IKLGMHSKNIRNEDEQIRVPRGKYFCLNTKFPNGLDKDIMLIRLRRPVTY
STHIAPVSLPSRSRGVGSRCRIMGWGKISTTTYPDVPHCTNIFIVKHKWC
EPLYPWVPADSRTLCAGILKGGRDTCHGDSGGPLICNGEMHGIVAGGSEP
CGQHLKPAVYTKVFDYNNWIQSIIAGNRTVTCPP
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain3s9c Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3s9c Structural basis of coagulation factor V recognition for cleavage by RVV-V
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y34 S38 K67 K73
Binding residue
(residue number reindexed from 1)		Y19 S24 K52 K58
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 H192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D88 H177 G178 D179 S180 G181
Enzyme Commision number 3.4.21.95: snake venom factor V activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3s9c, PDBe:3s9c, PDBj:3s9c
PDBsum3s9c
PubMed21871889
UniProtP18965|VSPG_DABSI Factor V activator RVV-V gamma

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