Structure of PDB 3rzj Chain A Binding Site BS02

Receptor Information

>3rzj Chain A (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSHSWRHIRAEGLDSSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVF
GKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQT
FNFVLINRYKDGSDHICEHRDDERELAPGSPIASVSFGASRDFVFRHKDS
RPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRK
ILL

Ligand information

>3rzj Chain C (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcgcagtgagaca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3rzj Duplex interrogation by a direct DNA repair protein in search of base damage
Resolution	2.5 Å
Binding residue (original residue number in PDB)	F102 G103 R241 K242
Binding residue (residue number reindexed from 1)	F50 G51 R186 K187

Enzymatic activity

Enzyme Commision number

1.14.11.33: DNA oxidative demethylase.

Gene Ontology

	Biological Process
GO:0006281	DNA repair

View graph for
Biological Process

External links

PDB	RCSB:3rzj, PDBe:3rzj, PDBj:3rzj
PDBsum	3rzj
PubMed	22659876
UniProt	Q6NS38\|ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (Gene Name=ALKBH2)

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