Structure of PDB 3rvb Chain A Binding Site BS02

Receptor Information
>3rvb Chain A (length=443) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAAT
LGFGVYMSKAHGIDPNIRTGVRAITTGGPITYSTYGKFLADGGCSAYDII
ICDECHSTDSTSILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIE
EVALSNTGEIPFYGKAIPIEVIRGGRHLIFCHSKKKCDELAAKLSALGLN
AVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVD
FSLDPTFTIDTTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGERPSGMFD
SSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFT
GLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKSLTR
LKPTLHGPTPLLYRLGALQNEVTLTHPVTKFIMACMSADLEVV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3rvb Chain A Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3rvb The structure of HCV NS3 helicase with inhibitor ITMN-3479
Resolution2.2 Å
Binding residue
(original residue number in PDB)		G209 S211 T212
Binding residue
(residue number reindexed from 1)		G24 S26 T27
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3rvb, PDBe:3rvb, PDBj:3rvb
PDBsum3rvb
PubMed
UniProtP26663|POLG_HCVBK Genome polyprotein

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