Structure of PDB 3rs0 Chain A Binding Site BS02

Receptor Information
>3rs0 Chain A (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
Ligand information
Ligand IDYEG
InChIInChI=1S/C5H10O/c6-5-3-1-2-4-5/h5-6H,1-4H2
InChIKeyXCIXKGXIYUWCLL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.2C1CCC(C1)O
ACDLabs 12.01
CACTVS 3.370		OC1CCCC1
FormulaC5 H10 O
Namecyclopentanol
ChEMBLCHEMBL288998
DrugBank
ZINCZINC000000901228
PDB chain3rs0 Chain A Residue 216 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3rs0 Analysis of Binding Site Hot Spots on the Surface of Ras GTPase.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		E37 D38 S39 Y71
Binding residue
(residue number reindexed from 1)		E37 D38 S39 Y71
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rs0, PDBe:3rs0, PDBj:3rs0
PDBsum3rs0
PubMed21945529
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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