Structure of PDB 3rrh Chain A Binding Site BS02

Receptor Information
>3rrh Chain A (length=538) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRD
LKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY
GGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHM
EATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVL
FDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKST
YIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRI
RRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETAS
WMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIE
RYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAA
ERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKE
RAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3rrh Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 A570 T571 R573 S575 S576 S577 D578 N580 Y671 M673 S674 R677 R728 S739 E742 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N189 N191 S192 S249 T250 T275 A276 T277 R279 S281 S282 S283 D284 N286 Y377 M379 S380 R383 R434 S445 E448 R452 M453 N456 Q460
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3rrh, PDBe:3rrh, PDBj:3rrh
PDBsum3rrh
PubMed22318723
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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