Structure of PDB 3rrg Chain A Binding Site BS02

Receptor Information
>3rrg Chain A (length=535) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALR
DLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARR
YGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAH
MEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERV
LFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKS
TYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQR
IRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETA
SWMFGVPRELMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYF
QSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERM
AFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAE
AVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3rrg Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)
N483 N485 S486 S543 T544 T569 A570 T571 S575 S576 S577 N580 Y671 S674 R728 R746 M747 Q754
Binding residue
(residue number reindexed from 1)
N190 N192 S193 S250 T251 T276 A277 T278 S282 S283 S284 N287 Y374 S377 R431 R449 M450 Q457
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function

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Biological Process
External links
PDB RCSB:3rrg, PDBe:3rrg, PDBj:3rrg
PDBsum3rrg
PubMed22318723
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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