Structure of PDB 3rma Chain A Binding Site BS02

Receptor Information
>3rma Chain A (length=894) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KEIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDGPI
SKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQSVF
SPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYVMS
FDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCSPN
GMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPNLS
VDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINR
KLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVC
GTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERM
EPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYA
LNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEES
LQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGIL
TYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIK
DDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMFDF
Ligand information
Receptor-Ligand Complex Structure
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PDB3rma A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		T622 M728 Q733 K734 S735 S784 N786 K790 Y791 H804
Binding residue
(residue number reindexed from 1)		T613 M719 Q724 K725 S726 S775 N777 K781 Y782 H795
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3rma, PDBe:3rma, PDBj:3rma
PDBsum3rma
PubMed21781974
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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