Structure of PDB 3qo8 Chain A Binding Site BS02

Receptor Information
>3qo8 Chain A (length=441) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLDINAFLVEKGGDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLD
EHNKKLNSVQKEIGKRFKDAKDLIAEKEKLSNEKKEIIEKEAEADKNLRS
KINQVGNIVHESVVDSQDEENNELVRTWTPENYKKPEQIAAATGAPAKLS
HHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSKG
YVPLQAPVMMNKEVMAKTAQLSQFDEELYKVIDGEDEKYLIATSEQPISA
YHAGEWFESPAEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQ
FVLTEPEKSWEEFDRMIGCSEEFYQSLGLPYRVVGIVSGELNNAAAKKYD
LEAWFPFQQEYKELVSCSNCTDYQSRNLEIRCGIKKYVHCLNSTLSATER
TICCILENYQKEDGLVIPEVLRKYIPGEPEFIPYIKELPKN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3qo8 Chain A Residue 487 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3qo8 Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E366 S369
Binding residue
(residue number reindexed from 1)		E363 S366
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R279 R294 E366 S369 R410
Catalytic site (residue number reindexed from 1) R276 R291 E363 S366 R400
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0140101 catalytic activity, acting on a tRNA
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3qo8, PDBe:3qo8, PDBj:3qo8
PDBsum3qo8
PubMed21825144
UniProtQ9HGT6|SYSC_CANAL Serine--tRNA ligase, cytoplasmic (Gene Name=SES1)

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