Structure of PDB 3pzp Chain A Binding Site BS02

Receptor Information
>3pzp Chain A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQI
TSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELK
DKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY
RAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIK
QNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN
GQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQR
ALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEE
QYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pzp Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer.
Resolution3.336 Å
Binding residue
(original residue number in PDB)		T44 S47 F49 M135 P153 F155 S388 T390 R413 K414 S415 S417 R420 T421 R507
Binding residue
(residue number reindexed from 1)		T20 S23 F25 M111 P129 F131 S308 T310 R333 K334 S335 S337 R340 T341 R427
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3pzp, PDBe:3pzp, PDBj:3pzp
PDBsum3pzp
PubMed21354175
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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