Structure of PDB 3pta Chain A Binding Site BS02

Receptor Information

>3pta Chain A (length=904) Species: 9606 (Homo sapiens)

AFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAM
KEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSY
YKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHW
FCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAME
GGMDPGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQ
KEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSS
PKEPVDEDLYPEHYRKYSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIK
IRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYG
EDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGKLPKLRTL
DVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCN
ILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSK
FKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGY
QCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLS
VVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEP
QSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNI
EVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVACDPAARQFNTLI
PWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHR
VVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCM
LAKA

Ligand information

>3pta Chain C (length=19)

cctgcggaggctcacggga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3pta Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): F648 R681 K683 K697
• Binding residue (residue number reindexed from 1): F2 R35 K37 K51

Enzymatic activity

• Catalytic site (original residue number in PDB): C1226 E1266 R1310 R1312
• Catalytic site (residue number reindexed from 1): C534 E574 R618 R620
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity
• GO:0008270 zinc ion binding

External links

• PDB: RCSB:3pta, PDBe:3pta, PDBj:3pta
• PDBsum: 3pta
• PubMed: 21163962
• UniProt: P26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)