Structure of PDB 3pt6 Chain A Binding Site BS02

Receptor Information

>3pt6 Chain A (length=914) Species: 10090 (Mus musculus)

MKRRRCGVCEVCQQPECGKCKACKDMVKFGGTGRSKQACLKRRCPNLAVK
EADDDEEADDDVSEMPSPKKLHQGKKKKQNKDRISWLGQPMKIEENRTYY
QKVSIDEEMLEVGDCVSVIPDDSSKPLYLARVTALWEDKNGQMMFHAHWF
CAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYKAPSENWAMEG
GKTYFFQLWYNQEYARFESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPK
VLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKVASPVKRP
KKDPVNETLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGKVN
EADIKLRLYKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQGRC
TVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKNFEDPPNHARSPGNKG
KGLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPG
TTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN
RFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRRSMVLKLT
LRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHV
FAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIQNGASN
SEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAARMRHIPLFPG
SDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCAEGKA
CDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMG
KQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNILDRHRQVGNAVPPPL
AKAIGLEIKLCLLS

Ligand information

>3pt6 Chain I (length=19)

cctgcggaggctcacggga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3pt6 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R684 S685 K686 K700 R1237
• Binding residue (residue number reindexed from 1): R34 S35 K36 K50 R551

Enzymatic activity

• Catalytic site (original residue number in PDB): C1229 E1269 R1313 R1315
• Catalytic site (residue number reindexed from 1): C543 E583 R627 R629
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity
• GO:0008270 zinc ion binding

External links

• PDB: RCSB:3pt6, PDBe:3pt6, PDBj:3pt6
• PDBsum: 3pt6
• PubMed: 21163962
• UniProt: P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)