Structure of PDB 3pr4 Chain A Binding Site BS02

Receptor Information
>3pr4 Chain A (length=341) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVLFVDFDYFAAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI
Ligand information
Receptor-Ligand Complex Structure
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PDB3pr4 Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		V32 A42 E219 A220 R242 K243 S244 I245 G246 R247 I248 T250 L293 R331 R332 R336
Binding residue
(residue number reindexed from 1)		V32 A42 E219 A220 R242 K243 S244 I245 G246 R247 I248 T250 L293 R331 R332 R336
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pr4, PDBe:3pr4, PDBj:3pr4
PDBsum3pr4
PubMed21295588
UniProtQ97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)

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