Structure of PDB 3pnc Chain A Binding Site BS02

Receptor Information
>3pnc Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEA
CSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTA
QMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTV
QKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLD
SLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALL
YFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRKVGPGRVLPTPTEKDV
FRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3pnc Replication infidelity via a mismatch with Watson-Crick geometry.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		W274 V462 G464 R514 R517 K521 L527 E529 H530 K544
Binding residue
(residue number reindexed from 1)		W25 V213 G215 R260 R263 K267 L273 E275 H276 K285
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D178 D180 D236
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3pnc, PDBe:3pnc, PDBj:3pnc
PDBsum3pnc
PubMed21233421
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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