Structure of PDB 3oyp Chain A Binding Site BS02

Receptor Information
>3oyp Chain A (length=174) Species: 11116 (Hepatitis C virus (isolate Japanese)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGV
CWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGS
SDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVV
GIFRAAVCTRGVAKAVDFIPVESM
Ligand information
Receptor-Ligand Complex Structure
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PDB3oyp Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		H57 D81 R155 A156 A157 C159
Binding residue
(residue number reindexed from 1)		H56 D80 R154 A155 A156 C158
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H56 D80 G136 S138
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3oyp, PDBe:3oyp, PDBj:3oyp
PDBsum3oyp
PubMed21113170
UniProtP26662|POLG_HCVJA Genome polyprotein

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