Structure of PDB 3os0 Chain A Binding Site BS02

Receptor Information
>3os0 Chain A (length=365) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH
Ligand information
Receptor-Ligand Complex Structure
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PDB3os0 The mechanism of retroviral integration from X-ray structures of its key intermediates
Resolution2.81 Å
Binding residue
(original residue number in PDB)		P214 E221 R222 S225 K228 K262
Binding residue
(residue number reindexed from 1)		P205 E212 R213 S216 K219 K253
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3os0, PDBe:3os0, PDBj:3os0
PDBsum3os0
PubMed21068843
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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