Structure of PDB 3ojs Chain A Binding Site BS02

Receptor Information
>3ojs Chain A (length=539) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALR
DLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARR
YGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAH
MEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERV
LFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKS
TYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQR
IRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETA
SWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFI
ERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREA
AERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPK
ERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
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PDB3ojs Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 I503 S513 S515 A517 S543 T544 T569 A570 T571 S575 S576 S577 D578 N580 F667 G668 Y671 G672 M673 S674 R677 Q680 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N190 N192 S193 I210 S220 S222 A224 S250 T251 T276 A277 T278 S282 S283 S284 D285 N287 F374 G375 Y378 G379 M380 S381 R384 Q387 R435 R453 M454 N457 Q461
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3ojs, PDBe:3ojs, PDBj:3ojs
PDBsum3ojs
PubMed21123743
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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