Structure of PDB 3og8 Chain A Binding Site BS02

Receptor Information

>3og8 Chain A (length=126) Species: 9606 (Homo sapiens)

KENKKLLCRKCKALACYTADVRVIEESHYTVLGDAFKECFVSRPHPKPKQ
FSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQ
TLYSKWKDFHFEKIPFDPAEMSKLEH

Ligand information

>3og8 Chain D (length=14)

ggcgcgcgcgcgcc

..............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3og8 Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): R811 F853
• Binding residue (residue number reindexed from 1): R9 F51

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

External links

• PDB: RCSB:3og8, PDBe:3og8, PDBj:3og8
• PDBsum: 3og8
• PubMed: 20961956
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)