Structure of PDB 3ngq Chain A Binding Site BS02

Receptor Information
>3ngq Chain A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPRPWITLKERDLPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYR
KKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAK
IMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRV
MTKDNIGVAVVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVSE
VKNILEKSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKECLMNFSC
EGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVEGVLGP
LDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3ngq Chain A Residue 558 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ngq Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D410 N412 H529
Binding residue
(residue number reindexed from 1)		D216 N218 H323
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3ngq, PDBe:3ngq, PDBj:3ngq
PDBsum3ngq
PubMed20628353
UniProtQ96LI5|CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (Gene Name=CNOT6L)

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