Structure of PDB 3ngd Chain A Binding Site BS02

Receptor Information
>3ngd Chain A (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSSGRESRQCPIPSHVIQKDVMTPMVD
ILMKLFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3ngd Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 E97 L99 P299 Q300 S303 E305 S307 R331 R347
Binding residue
(residue number reindexed from 1)		Q34 K35 Y36 E72 L74 P274 Q275 S278 E280 S282 R306 R322
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3ngd, PDBe:3ngd, PDBj:3ngd
PDBsum3ngd
PubMed20961860
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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