Structure of PDB 3nbn Chain A Binding Site BS02

Receptor Information

>3nbn Chain A (length=423) Species: 9606 (Homo sapiens)

PPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYL
MGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTA
KTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLK
NADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLL
DDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLD
ADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDG
ASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTG
QNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVP
VTLVRNDGIIYSTSLTFTYTPEP

Ligand information

>3nbn Chain Y (length=37)

actcgtgtgaaacttcccaaactttctttcccacagt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3nbn Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
• Resolution: 3.45 Å
• Binding residue (original residue number in PDB): Y46 S151 S154 K156 S159 K161 R180 Q182
• Binding residue (residue number reindexed from 1): Y35 S140 S143 K145 S148 K150 R169 Q171

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3nbn, PDBe:3nbn, PDBj:3nbn
• PDBsum: 3nbn
• PubMed: 20972443
• UniProt: Q06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)