Structure of PDB 3nai Chain A Binding Site BS02

Receptor Information
>3nai Chain A (length=486) Species: 223997 (Murine norovirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDER
VDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKP
WTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEM
GKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFC
DALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRA
ILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCP
CTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLEL
DMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWY
GRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEK
YYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGT
Ligand information
Ligand IDURF
InChIInChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKeyGHASVSINZRGABV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=C(C(=O)NC(=O)N1)F
ACDLabs 10.04
CACTVS 3.341		FC1=CNC(=O)NC1=O
FormulaC4 H3 F N2 O2
Name5-FLUOROURACIL
ChEMBLCHEMBL185
DrugBankDB00544
ZINCZINC000038212689
PDB chain3nai Chain A Residue 521 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3nai Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase
Resolution2.56 Å
Binding residue
(original residue number in PDB)		D346 D347
Binding residue
(residue number reindexed from 1)		D340 D341
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3nai, PDBe:3nai, PDBj:3nai
PDBsum3nai
PubMed
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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