Structure of PDB 3mxi Chain A Binding Site BS02

Receptor Information
>3mxi Chain A (length=219) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLNLEATGLPSSRPEVTELCLLAVHRRALESQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYGT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3mxi Chain A Residue 243 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3mxi X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants
Resolution2.55 Å
Binding residue
(original residue number in PDB)		N18 E20 H195 D200
Binding residue
(residue number reindexed from 1)		N14 E16 H179 D184
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3mxi, PDBe:3mxi, PDBj:3mxi
PDBsum3mxi
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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