Structure of PDB 3mvf Chain A Binding Site BS02

Receptor Information

>3mvf Chain A (length=184) Species: 13249 (Rhodnius prolixus)

ACTKNAIAQTGFNKDKYFNGDVWYVTDYLDLEPDDVPKRYCAALAAGTAS
GKLKEALYHYDPKTQDTFYDVSELQVESLGKYTANFKKVDKNGNVKVAVT
AGNYYTFTVMYADDSSALIHTCLHKGNKDLGDLYAVLNRNKDAAAGDKVK
SAVSAATLEFSKFISTKENNCAYDNDSLKSLLTK

Ligand information

• Ligand ID: NO2
• InChI: InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1
• InChIKey: IOVCWXUNBOPUCH-UHFFFAOYSA-M
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341: [O-]N=O
  OpenEye OEToolkits 1.5.0: N(=O)[O-]
• Formula: N O2
• Name: NITRITE ION
• DrugBank: DB12529
• PDB chain: 3mvf Chain A Residue 187

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3mvf Formation of the complex of nitrite with the ferriheme b beta-barrel proteins nitrophorin 4 and nitrophorin 7.
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): D66 K88
• Binding residue (residue number reindexed from 1): D66 K88
• Annotation score: 5

Enzymatic activity

• Catalytic site (original residue number in PDB): D30 H59 L130
• Catalytic site (residue number reindexed from 1): D30 H59 L130
• Enzyme Commision number: 1.7.6.1: nitrite dismutase.

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051381 histamine binding
• GO:0070026 nitric oxide binding

Biological Process

• GO:0042311 vasodilation

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:3mvf, PDBe:3mvf, PDBj:3mvf
• PDBsum: 3mvf
• PubMed: 20524697
• UniProt: Q94734|NP4_RHOPR Nitrophorin-4