Structure of PDB 3mq3 Chain A Binding Site BS02

Receptor Information

>3mq3 Chain A (length=378) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PPQVNSILKANEYSFKVPEFDGKNVSSVLGFDSNQLPANAPIEDRRSAAT
CLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENALL
PILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDIDVKEALINAFKRLDN
DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAM
LGVQEEDGSWSAVTLSNDHNAQNEREVERLKLEHPKNEAKSVVKQDRLLG
LLMPFRAFGDVKFKWSIDLQKRVIEKFIPPNYYTPPYLTAEPEVTYHRLR
PQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMQNAATHLIRHAVKMLSL
PEELARMYRDDITIIVVQFNSHVVGAYQ

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

3mq3 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3mq3 Crystal Structure of Catalytic Subunit of Bovine Pyruvate Dehydrogenase Phophatase
Resolution	2.8 Å
Binding residue (original residue number in PDB)	D73 D347 D445
Binding residue (residue number reindexed from 1)	D63 D311 D360
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.43: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase.

Gene Ontology

	Molecular Function
GO:0004722	protein serine/threonine phosphatase activity
GO:0043169	cation binding

	Biological Process
GO:0006470	protein dephosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:3mq3, PDBe:3mq3, PDBj:3mq3
PDBsum	3mq3
PubMed
UniProt	P35816\|PDP1_BOVIN [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (Gene Name=PDP1)

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