Structure of PDB 3mkv Chain A Binding Site BS02

Receptor Information
>3mkv Chain A (length=414) Species: 32644 (unidentified) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTTFLFRNGALLDPDHPDLLQGFEILIEDGFIREVSDKPIKSSNAHVIDV
KGKTIMPGLIDLHVHVVAIEFNLPRVATLPNVLVTLRAVPIMRAMLRRGF
TTVRDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSDYM
PPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVAS
PTDPVGVFGYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVRCGVRTI
EHGNLIDDETARLVAEHGAYVVPTLVTYDALASEGEKYGLPPESIAKIAD
VHGAGLHSIEIMKRAGVKMGFGTDLLGEAQRLQSDEFRILAEVLSPAEVI
ASATIVSAEVLGMQDKLGRIVPGAHADVLVVDGNPLKSVDCLLGQGEHIP
LVMKDGRLFVNELE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3mkv Chain A Residue 426 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mkv Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily .
Resolution2.4 Å
Binding residue
(original residue number in PDB)		K191 H232 H252
Binding residue
(residue number reindexed from 1)		K191 H232 H252
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3mkv, PDBe:3mkv, PDBj:3mkv
PDBsum3mkv
PubMed20604542
UniProtB2T4I1

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