Structure of PDB 3mfi Chain A Binding Site BS02

Receptor Information
>3mfi Chain A (length=511) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPHMSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSK
EDPVVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKK
GEDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALAIFKWACD
LVERASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGG
NYDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKG
IRDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDC
GKFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLD
AKVKQSDYDSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKN
LRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTK
SYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLS
MTITNFDIIDL
Ligand information
Receptor-Ligand Complex Structure
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PDB3mfi Structural basis for the suppression of skin cancers by DNA polymerase eta.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		Q55 W56 M74 K125 R132 R389 K393 S394 M395 M396 N398 N400 R426 Y452
Binding residue
(residue number reindexed from 1)		Q58 W59 M77 K128 R135 R389 K393 S394 M395 M396 N398 N400 R426 Y452
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfi, PDBe:3mfi, PDBj:3mfi
PDBsum3mfi
PubMed20577207
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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