Structure of PDB 3mfh Chain A Binding Site BS02

Receptor Information
>3mfh Chain A (length=510) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKEDP
VVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKGED
FWQYHDGCGSWVPAKQISVEDHKVSLEPYRRESRKALAIFKWACDLVERA
SIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGNYDIN
SHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGIRDSI
KDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCGKFEI
TSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDAKVKQ
SDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKNLR
GKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTKSY
EVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLSMT
ITNFDIIDLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mfh Structural basis for the suppression of skin cancers by DNA polymerase eta.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q55 W56 R73 M74 K125 V126 R132 R389 K393 S394 M395 M396 N398 N400 R426
Binding residue
(residue number reindexed from 1)		Q55 W56 R73 M74 K123 V124 R130 R387 K391 S392 M393 M394 N396 N398 R424
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfh, PDBe:3mfh, PDBj:3mfh
PDBsum3mfh
PubMed20577207
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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