Structure of PDB 3mdc Chain A Binding Site BS02

Receptor Information
>3mdc Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIP
GIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWY
QQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAA
QAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQ
EGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACAL
LYFTGSAHFNRSMRALAKTKGMSLSEHALSTAGPGRVLPTPTEKDVFRLL
GLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3mdc Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
Resolution1.999 Å
Binding residue
(original residue number in PDB)		W342 G343 G345 K347 T348 R488 D490 Y505
Binding residue
(residue number reindexed from 1)		W89 G90 G92 K94 T95 R235 D237 Y252
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D174 D176 D237
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mdc, PDBe:3mdc, PDBj:3mdc
PDBsum3mdc
PubMed20348107
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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