Structure of PDB 3mbi Chain A Binding Site BS02

Receptor Information

>3mbi Chain A (length=287) Species: 50339 (Thermoplasma volcanium)

SGMKIIALRSSLKLAARIAEELKTEPVMPDERRFPDGELYLRYDEDLTGH
NIFIIGNTHSDAEVMEMILTLSAIQDYRTKSVNIIAPYYGYARQHQRYKN
GEPISSQILTEIYSSYSNSIATVDIHDEKTLSYSKVKFSDLHANDAIVRY
YKNVDVDYVVSPDDGGLARVADISAKLGKKHFFIEKKRIDDRTVEMKVPN
VDVNGKKLLIVDDIISTGGTIAKSSGLLREKGASKIYVSAVHGLFVNGSE
NKILQNADEIHVTDTVESKFSDISVYQEVCNYIRDID

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3mbi Chain A Residue 287

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3mbi The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): H93 H124
• Binding residue (residue number reindexed from 1): H95 H126
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.6.1: ribose-phosphate diphosphokinase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004749 ribose phosphate diphosphokinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
• GO:0006164 purine nucleotide biosynthetic process
• GO:0009165 nucleotide biosynthetic process
• GO:0016310 phosphorylation

Cellular Component

• GO:0002189 ribose phosphate diphosphokinase complex
• GO:0005737 cytoplasm

External links

• PDB: RCSB:3mbi, PDBe:3mbi, PDBj:3mbi
• PDBsum: 3mbi
• PubMed: 21963988
• UniProt: Q97CA5|KPRS_THEVO Ribose-phosphate pyrophosphokinase (Gene Name=prs)