Structure of PDB 3lwv Chain A Binding Site BS02

Receptor Information

>3lwv Chain A (length=317) Species: 2261 (Pyrococcus furiosus)

RILPADIKREVLIKDENAETNPDWGFPPEKRPIEMHIQFGVINLDKPPGP
TSHEVVAWIKKILNLEKAGHGGTLDPKVSGVLPVALEKATRVVQALLPAG
KEYVALMHLHGDVPEDKIIQVMKEFEGEIIQRLRTRKVYYIEVLEIEGRD
VLFRVGVEAGTYIRSLIHHIGLALGVGAHMSELRRTRSGPFKEDETLITL
HDLVDYYYFWKEDGIEEYFRKAIQPMEKAVEHLPKVWIKDSAVAAVTHGA
DLAVPGIAKLHAGIKRGDLVAIMTLKDELVALGKAMMTSQEMLEKTKGIA
VDVEKVFMPRDWYPKLW

Ligand information

>3lwv Chain E (length=11)

gagcgcgguuu

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3lwv Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase .
• Resolution: 2.499 Å
• Binding residue (original residue number in PDB): H63 T83
• Binding residue (residue number reindexed from 1): H53 T73

Enzymatic activity

• Catalytic site (original residue number in PDB): D85 Y113 R184
• Catalytic site (residue number reindexed from 1): D75 Y103 R164
• Enzyme Commision number: 5.4.99.25: tRNA pseudouridine(55) synthase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0009982 pseudouridine synthase activity
• GO:0016853 isomerase activity
• GO:0160148 tRNA pseudouridine(55) synthase activity

Biological Process

• GO:0000495 box H/ACA sno(s)RNA 3'-end processing
• GO:0001522 pseudouridine synthesis
• GO:0006396 RNA processing
• GO:0008033 tRNA processing
• GO:0009451 RNA modification
• GO:0031118 rRNA pseudouridine synthesis
• GO:0031119 tRNA pseudouridine synthesis
• GO:0031120 snRNA pseudouridine synthesis
• GO:1990481 mRNA pseudouridine synthesis

External links

• PDB: RCSB:3lwv, PDBe:3lwv, PDBj:3lwv
• PDBsum: 3lwv
• PubMed: 20575532
• UniProt: Q7LWY0|TRUB_PYRFU Probable tRNA pseudouridine synthase B (Gene Name=truB)