Structure of PDB 3lwl Chain A Binding Site BS02

Receptor Information
>3lwl Chain A (length=534) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRD
LKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRY
GGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHM
EATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVL
FDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKST
YIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRI
RRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETAS
WMFGVPRELMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQ
SFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMA
FNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEA
VARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3lwl Replication through an abasic DNA lesion: structural basis for adenine selectivity
Resolution2.25 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 A570 T571 S575 S576 S577 D578 N580 Y671 M673 S674 H676 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N189 N191 S192 S249 T250 T275 A276 T277 S281 S282 S283 D284 N286 Y373 M375 S376 H378 R430 R448 M449 N452 Q456
Binding affinityPDBbind-CN: Kd=149uM
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3lwl, PDBe:3lwl, PDBj:3lwl
PDBsum3lwl
PubMed20400942
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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