Structure of PDB 3lr7 Chain A Binding Site BS02

Receptor Information

>3lr7 Chain A (length=151) Species: 9796 (Equus caballus)

GLSDGEWQQVLNVWGKVEADIAGHGQEVLIRLFTGHPETLEKFDKFKHLK
TEAEMKASEDLKKHGTVVLTALGGILKKKGHHEAELKPLAQSHATKHKIP
IKYLEFISDAIIHVLHSKHPGDFGADAQGAMTKALELFRNDIAAKYKELG
F

Ligand information

• Ligand ID: NO2
• InChI: InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1
• InChIKey: IOVCWXUNBOPUCH-UHFFFAOYSA-M
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341: [O-]N=O
  OpenEye OEToolkits 1.5.0: N(=O)[O-]
• Formula: N O2
• Name: NITRITE ION
• DrugBank: DB12529
• PDB chain: 3lr7 Chain A Residue 155

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3lr7 Synchrotron X-ray-Induced Photoreduction of Ferric Myoglobin Nitrite Crystals Gives the Ferrous Derivative with Retention of the O-Bonded Nitrite Ligand.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): H64 V68
• Binding residue (residue number reindexed from 1): H64 V68
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 1.11.1.-
  1.7.-.-

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0005344 oxygen carrier activity
• GO:0016491 oxidoreductase activity
• GO:0019825 oxygen binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0098809 nitrite reductase activity

Biological Process

• GO:0015671 oxygen transport
• GO:0019430 removal of superoxide radicals

Cellular Component

• GO:0005737 cytoplasm
• GO:0016528 sarcoplasm

External links

• PDB: RCSB:3lr7, PDBe:3lr7, PDBj:3lr7
• PDBsum: 3lr7
• PubMed: 20568729
• UniProt: P68082|MYG_HORSE Myoglobin (Gene Name=MB)