Structure of PDB 3l2p Chain A Binding Site BS02

Receptor Information
>3l2p Chain A (length=535) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGGDVYLTVKLLL
PGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQS
KSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKC
IIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEV
ELSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKN
GDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTG
KPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHD
NMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPG
KRHWLKVKKDYLNMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQK
WCTVTKCAGGHDDATLARLQNELDMVKISKAAVWEITGAEFSKSEAHTAD
GISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK
Ligand information
Receptor-Ligand Complex Structure
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PDB3l2p Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P190 S191 Y192 N193 R441 R584 K588 Y593 H646 D647 D648 F717 R719
Binding residue
(residue number reindexed from 1)		P23 S24 Y25 N26 R259 R402 K406 Y411 H461 D462 D463 F506 R508
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3l2p, PDBe:3l2p, PDBj:3l2p
PDBsum3l2p
PubMed20518483
UniProtP49916|DNLI3_HUMAN DNA ligase 3 (Gene Name=LIG3)

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