Structure of PDB 3kvy Chain A Binding Site BS02

Receptor Information
>3kvy Chain A (length=290) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVQLCNPHIAAMKEDILYHFSLSTSTHDFPAMFGDVKFVCVGGSPSRMK
AFIKYVAMELGFAADYPNICEGTDRYAMFKVGPVLSVSHGMGVPSIAIML
HELIKLLYHAHCSGVTLIRIGTSGGIGLEPGSVVITRQAVDPCFKPEFEQ
IVLGKREVRNTDLDEQLVQELARCSAELGEFPTVVGNTMCTLDFYEGQGR
LDGALCSYTEKDKQDYLRAAYAAGIRNIEMEASVFAAMCNACGLRAAVVC
VTLLNRLEGDQISSPHDVLAEYQQRPQRLVGQFIKKRLMQ
Ligand information
Ligand IDURA
InChIInChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKeyISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC=CC(=O)N1
ACDLabs 10.04O=C1C=CNC(=O)N1
OpenEye OEToolkits 1.5.0C1=CNC(=O)NC1=O
FormulaC4 H4 N2 O2
NameURACIL
ChEMBLCHEMBL566
DrugBankDB03419
ZINCZINC000000895045
PDB chain3kvy Chain A Residue 312 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3kvy Glycal formation in crystals of uridine phosphorylase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S141 G142 F212 Q216 R218 I246 E247 M248
Binding residue
(residue number reindexed from 1)		S123 G124 F194 Q198 R200 I228 E229 M230
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) E120 R274
Catalytic site (residue number reindexed from 1) E102 R256
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0009166 nucleotide catabolic process
GO:0044206 UMP salvage
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3kvy, PDBe:3kvy, PDBj:3kvy
PDBsum3kvy
PubMed20364833
UniProtA5PJH9

[Back to BioLiP]