Structure of PDB 3kvr Chain A Binding Site BS02

Receptor Information

>3kvr Chain A (length=293) Species: 9913 (Bos taurus)

LVQLCNPHIAAMKEDILYHFSLSTSTHDFPAMFGDVKFVCVGGSPSRMKA
FIKYVAMELGFAHPGADYPNICEGTDRYAMFKVGPVLSVSHGMGVPSIAI
MLHELIKLLYHAHCSGVTLIRIGTSGGIGLEPGSVVITRQAVDPCFKPEF
EQIVLGKREVRNTDLDEQLVQELARCSAELGEFPTVVGNTMCTLDFYEGQ
GRLDGALCSYTEKDKQDYLRAAYAAGIRNIEMEASVFAAMCNACGLRAAV
VCVTLLNRLEGDQISSPHDVLAEYQQRPQRLVGQFIKKRLMQA

Ligand information

• Ligand ID: SO4
• InChI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
• InChIKey: QAOWNCQODCNURD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-]S(=O)(=O)[O-]
  CACTVS 3.341: [O-][S]([O-])(=O)=O
  ACDLabs 10.04: [O-]S([O-])(=O)=O
• Formula: O4 S
• Name: SULFATE ION
• DrugBank: DB14546
• PDB chain: 3kvr Chain A Residue 310

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3kvr Glycal formation in crystals of uridine phosphorylase.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): G59 R63 R137 T140
• Binding residue (residue number reindexed from 1): G43 R47 R121 T124
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E120 R274
• Catalytic site (residue number reindexed from 1): E104 R258
• Enzyme Commision number: 2.4.2.3: uridine phosphorylase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004850 uridine phosphorylase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0047847 deoxyuridine phosphorylase activity

Biological Process

• GO:0009116 nucleoside metabolic process
• GO:0009164 nucleoside catabolic process
• GO:0009166 nucleotide catabolic process
• GO:0044206 UMP salvage

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3kvr, PDBe:3kvr, PDBj:3kvr
• PDBsum: 3kvr
• PubMed: 20364833
• UniProt: A5PJH9