Structure of PDB 3kva Chain A Binding Site BS02
Receptor Information
>3kva Chain A (length=366) Species:
9606
(Homo sapiens) [
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PVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVP
KLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKY
FMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPK
PFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLAR
YESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCM
AFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLET
LKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGH
LIKELSKVIRAIEEEN
Ligand information
Ligand ID
FE2
InChI
InChI=1S/Fe/q+2
InChIKey
CWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Fe+2]
CACTVS 3.341
[Fe++]
Formula
Fe
Name
FE (II) ION
ChEMBL
DrugBank
DB14510
ZINC
PDB chain
3kva Chain A Residue 490 [
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Receptor-Ligand Complex Structure
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PDB
3kva
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Resolution
2.79 Å
Binding residue
(original residue number in PDB)
S249 W250 V251 F369 L370
Binding residue
(residue number reindexed from 1)
S136 W137 V138 F256 L257
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.14.11.65
: [histone H3]-dimethyl-L-lysine(9) demethylase.
External links
PDB
RCSB:3kva
,
PDBe:3kva
,
PDBj:3kva
PDBsum
3kva
PubMed
20023638
UniProt
Q6ZMT4
|KDM7A_HUMAN Lysine-specific demethylase 7A (Gene Name=KDM7A)
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