Structure of PDB 3ks9 Chain A Binding Site BS02

Receptor Information

>3ks9 Chain A (length=445) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFH
TLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLKPIAGVI
GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTL
QARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLSIAHSDK
IYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVG
EFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGPNFKRICTGNESLEENYVQDSKMGFVIN
AIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGE
EVWFDEKGDAPGRYDIMNLQYTERYDYVHVGTWHEGVLNIDDYKI

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3ks9 Chain A Residue 524 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ks9 Metabotropic glutamate receptor mglur1 complexed with LY341495 antagonist
Resolution	1.9 Å
Binding residue (original residue number in PDB)	I89 N90 D92 L95 L96
Binding residue (residue number reindexed from 1)	I55 N56 D58 L61 L62
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3ks9, PDBe:3ks9, PDBj:3ks9
PDBsum	3ks9
PubMed
UniProt	Q13255\|GRM1_HUMAN Metabotropic glutamate receptor 1 (Gene Name=GRM1)

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