Structure of PDB 3kn2 Chain A Binding Site BS02

Receptor Information
>3kn2 Chain A (length=181) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS
Ligand information
>3kn2 Chain D (length=16) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB3kn2 P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T4 A5 Y6 A7
Binding residue
(residue number reindexed from 1)		T4 A5 Y6 A7
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3kn2, PDBe:3kn2, PDBj:3kn2
PDBsum3kn2
PubMed20004570
UniProtP26664|POLG_HCV1 Genome polyprotein

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