Structure of PDB 3klv Chain A Binding Site BS02

Receptor Information

>3klv Chain A (length=476) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

Ligand information

>3klv Chain C (length=5)

ggccc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3klv Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): S304 Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426
• Binding residue (residue number reindexed from 1): S304 Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3klv, PDBe:3klv, PDBj:3klv
• PDBsum: 3klv
• PubMed: 20392853
• UniProt: Q9QCE3