Structure of PDB 3k9n Chain A Binding Site BS02

Receptor Information
>3k9n Chain A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEFDPTIEDSYRKQVVIDGET
CLLDILDTAGQYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKR
VKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGV
EDAFYTLVREIRQH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3k9n Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3k9n Allosteric modulation of Ras positions Q61 for a direct role in catalysis.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R102 D105
Binding residue
(residue number reindexed from 1)		R100 D103
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k9n, PDBe:3k9n, PDBj:3k9n
PDBsum3k9n
PubMed20194776
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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