Structure of PDB 3k1l Chain A Binding Site BS02

Receptor Information
>3k1l Chain A (length=376) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDVERLLCQKYPGLAAELQPSGACIIRGVLGSEDTWRRLKLYLPHHPALH
GFQLYVQESLEYKLYTSANLKLQDDWLLEDFLDHLPKILPAQKAPTVPEL
CREGNIYYDILALYKSNEYCLQVDEACSMIRFSEFTDFEQHYLELKIPSL
LLLDHSLPDCVSLGEMLTKSAGNLEEALNLFRKLLEDLRPFYDNFMDIDE
LCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASMSLKIIGPTE
EVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEED
NEELRCNICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKT
FLEVSFGQCPFCKAKLSTSFAALLND
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3k1l Chain A Residue 382 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3k1l The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C329 C334 C364 C367
Binding residue
(residue number reindexed from 1)		C324 C329 C359 C362
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3k1l, PDBe:3k1l, PDBj:3k1l
PDBsum3k1l
PubMed20154706
UniProtQ8T913|FANCL_DROME E3 ubiquitin-protein ligase Fancl (Gene Name=Fancl)

[Back to BioLiP]