Structure of PDB 3jca Chain A Binding Site BS02

Receptor Information
>3jca Chain A (length=262) Species: 11757 (Mouse mammary tumor virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPHAPQLGVNP
RGLKPRVLWQMDVTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVL
QHLAQSFAYMGIPQKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQG
QAIVERTHQNIKAQLNKLQKAGKYYTPHHLLAHALFVLNHVNMDNQGHTA
AERHWGPISADPKPMVMWKDLLTGSWKGPDVLITAGRGYACVFPQDAESP
IWVPDRFIRPFT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jca Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		Q152 E158 R159 Q162 R240
Binding residue
(residue number reindexed from 1)		Q149 E155 R156 Q159 R237
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3jca, PDBe:3jca, PDBj:3jca
PDBsum3jca
PubMed26887496
UniProtP03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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