Structure of PDB 3iqx Chain A Binding Site BS02

Receptor Information

>3iqx Chain A (length=261) Species: 209285 (Thermochaetoides thermophila)

SMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLLS
TDPAHNLSDAFSQKFGKEARLVEGFDNLYAMEIDPAIPGIDEAMSFAEVL
KQVNSLSYETIVFDTAPTGHTLRFLQFPTVLDVMEKLDSLRVTISEVNAQ
FKDERLTTFVCVCIPEFLSLYETERMIQELANYGIDTHCIVVNQLLFPKP
GSDCEQCTARRRMQKKYLDQIEELYDEEFNVVKMPLLVEEVRGKERLEKF
SEMLIKPFVPP

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3iqx Chain A Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3iqx Structural insights into tail-anchored protein binding and membrane insertion by Get3.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): C281 C284
• Binding residue (residue number reindexed from 1): C204 C207
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): G37 G39 K40 T41 T42 D64
• Catalytic site (residue number reindexed from 1): G25 G27 K28 T29 T30 D52

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
• GO:0045048 protein insertion into ER membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0043529 GET complex

External links

• PDB: RCSB:3iqx, PDBe:3iqx, PDBj:3iqx
• PDBsum: 3iqx
• PubMed: 19948960
• UniProt: G0SFE0