Structure of PDB 3hfw Chain A Binding Site BS02

Receptor Information

>3hfw Chain A (length=357) Species: 9606 (Homo sapiens)

MEKYVAAMVLSAAGDALGYYNGKWEFLQDGEKIHRQLAQLGGLDALDVGR
WRVSDDTVMHLATAEALVEAGKAPKLTQLYYLLAKHYQDCMEDMDGRAPG
GASVHNAMQLKPGKPNGWRIPFNSHEGGCGAAMRAMCIGLRFPHHSQLDT
LIQVSIESGRMTHHHPTGYLGALASALFTAYAVNSRPPLQWGKGLMELLP
EAKKYIVQSGYFVEENLQHWSYFQTKWENYLKLRGILDGESAPTFPESFG
VKERDQFYTSLSYSGWGGSSGHDAPMIAYDAVLAAGDSWKELAHRAFFHG
GDSDSTAAIAGCWWGVMYGFKGVSPSNYEKLEYRNRLEETARALYSLGSK
EDTVISL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3hfw Chain A Residue 361

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3hfw Crystal Structure of human ADP-ribosylhydrolase 1
• Resolution: 1.92 Å
• Binding residue (original residue number in PDB): S54 D55 D56 D304
• Binding residue (residue number reindexed from 1): S54 D55 D56 D304
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.2.2.19: [protein ADP-ribosylarginine] hydrolase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003875 ADP-ribosylarginine hydrolase activity
• GO:0005515 protein binding
• GO:0016787 hydrolase activity
• GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
• GO:0030955 potassium ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0036211 protein modification process
• GO:0051725 protein de-ADP-ribosylation

Cellular Component

• GO:0005615 extracellular space

External links

• PDB: RCSB:3hfw, PDBe:3hfw, PDBj:3hfw
• PDBsum: 3hfw
• UniProt: P54922|ADPRH_HUMAN ADP-ribosylhydrolase ARH1 (Gene Name=ADPRH)