Structure of PDB 3h5x Chain A Binding Site BS02

Receptor Information
>3h5x Chain A (length=470) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRVKG
GPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDKWS
FAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEEGK
NMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMDE
LKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDP
EKLTAKLKEYGLKPTPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSIL
RQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAFYSKISKLV
IAEDFYVPRQEPMFRWMRFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3h5x Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.
Resolution1.77 Å
Binding residue
(original residue number in PDB)		T117 S118 K127 A164 K166 L184 G186 M192 K207 G218 M219 N220 S300 G301 P303 Y341 N422 Q439
Binding residue
(residue number reindexed from 1)		T112 S113 K122 A159 K161 L179 G181 M187 K202 G213 M214 N215 S295 G296 P298 Y336 N410 Q427
Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3h5x, PDBe:3h5x, PDBj:3h5x
PDBsum3h5x
PubMed19426741
UniProtQ70ET3

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