Structure of PDB 3h2x Chain A Binding Site BS02

Receptor Information
>3h2x Chain A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAE
KPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYI
ATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQ
LEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPS
SIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDG
IIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HS
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain3h2x Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3h2x Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation .
Resolution2.2 Å
Binding residue
(original residue number in PDB)		K51 K53 N54 S82 S83
Binding residue
(residue number reindexed from 1)		K51 K53 N54 S82 S83
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D195 C227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) D195 C227 R233 T234 Q274
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3h2x, PDBe:3h2x, PDBj:3h2x
PDBsum3h2x
PubMed19371084
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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